Background: The newly discovered SARS-CoV-2 virus causes COVID-19. Since the WHO classified SARS-CoV-2 a worldwide pandemic, COVID-19 has spread to 223 countries with over 281 million illnesses and 5.4 million deaths. Various medical, social, and engineering strategies have been proposed to combat COVID-19, including therapy, prevention, detection, and prediction. Knowledge, awareness, risk perception, and efficacy belief inspire preventive behaviour, according to infectious disease studies. The aim of study to investigate COVID-19 preventive knowledge, attitude, and self-reported practise among Al-Imamain Al-Kadhmain Medical City/Baghdad patients. To identify Sociodemographic factors affecting participant knowledge and attitude towards COVID-19 prevention.

Method: A three-month cross-sectional analytic study at Al-Imamain Al-Kadhmain Medical City/Baghdad from January 2 to April 1, 2022. It included 300 adults who visited the hospital's outpatient clinic for whatever reason. The data was acquired using a five-part questionnaire: Participants' socio-demographics, vaccination status, COVID-19 virus prevention knowledge, attitude, and practice.

Results: This research found 73.6% fair to good knowledge, 80% favourable attitudes, and 67.7% good practise. Younger individuals, males, rural residents, illiterate, jobless, and non-COVID-19 vaccinees had poor knowledge. Participants aged 40-49, urban residents, highly educated, and COVID-19 vaccinees had a considerably greater positive attitude. Mask face was the most common preventive method (82%), followed by hand cleaning (75.7%). A substantial correlation existed between participant knowledge and practise.

Conclusion: Many study participants had good knowledge, positive attitudes, and effective practises for COVID-19 prevention. Participant knowledge of age, gender, domicile, education, occupation, and immunisation.